![]() ![]() These integrated omics results provide unbiased and comprehensive information for the further understanding of the molecular mechanisms of LNB. Furthermore, based on the analysis of omics data, translational regulation, glycosaminoglycan/proteoglycan-binding activity in colonization and dissemination to tissues, disease-associated genes, and synaptic function were enriched, which potentially play a role in pathogenesis during the interaction between frontal cortex tissues and spirochetes. Through bioinformatics analysis, a complex network of enriched pathways that were mobilized during the progression of Lyme spirochete infection was described. ![]() Then, we analyzed identified mRNA and proteins in the frontal cortex tissues, allowing for an in-depth view of the transcriptome and proteome for a macroscopic and unbiased understanding of early disseminated Lyme disease in the brain. It is a cellular layer that is composed of proteins, carbohydrates and hyaluronic acid. Explants from the frontal cortex of 3 rhesus brains were incubated with medium alone or with medium containing live Bb for 6, 12, or 24 hours. Corona radiata is a thick outer layer that surrounds the zona pellucida. Presently, there is a lack of knowledge of the changes in mRNA and proteins in the CNS following early disseminated Lyme disease. The pathogenesis of Lyme neuroborreliosis (LNB) remains poorly understood. Prognosis is good with appropriate antibiotic treatment, but additional immunosupressive treatment is sometimes needed.īorrelia burgdorferi (Bb), which is neurotropic, can attack the central nervous system (CNS), leading to the development of various neurologic symptoms. Lyme neuroborreliosis–associated vasculopathy and cerebrovascular events still remain rare but should be considered especially in Lyme borreliosis endemic areas. Clinical outcomes for all our patients were good with a modified Rankin scale (mRS) 0–2. Vasculitis as a manifestation of borreliosis was diagnosed in six patients of 1454 (0.4%) and stroke or TIA in nine (0.6%) of all borreliosis patients at Helsinki University Hospital. We have identified 10 cases of neuroborreliosis–associated stroke or TIA and/or vasculitis. Neuroborreliosis was diagnosed according to the European Federation of Neurological Societies guidelines. Medical data and follow-up data were retrospectively collected from medical records. We have retrospectively identified all adult patients (>16 years old) diagnosed with borreliosis (A69.2 Lyme borreliosis), transient ischemic attack (TIA, G45), and ischemic stroke (I63) at Helsinki University Hospital during – at our neurological emergency department. The incidence of Lyme borreliosis in Finland has been increasing in the last 20 years, so we expect that Lyme neuroborreliosis–associated vasculitis can be a more common cause of stroke in the future. Neuroborreliosis is a rare cause of cerebral vasculitis and stroke. ![]()
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